Comparison of Sculptra vs. Radiesse
Both Sculptra and Radiesse are biostimulatory dermal fillers designed to enhance volume and improve skin quality by stimulating collagen production. However, they differ in composition, longevity, and areas of use.
| Feature | Sculptra (PLLA) | Radiesse (CaHA) |
|---|---|---|
| Main Ingredient | Poly-L-Lactic Acid (PLLA) | Calcium Hydroxylapatite (CaHA) microspheres |
| Mechanism of Action | Collagen stimulator (gradual volume restoration over months) | Collagen stimulator & filler (immediate volume with long-term collagen stimulation) |
| Immediate Volume Effect? | ❌ No (gradual improvement over 3–6 months) | ✅ Yes (initial filling effect, then collagen builds over time) |
| Longevity | 2–3 years | 12–18 months |
| Best for | Deep facial volume loss (cheeks, temples, jawline), skin tightening | Midface volume loss, jawline contouring, hand rejuvenation |
| Texture & Feel | Thin, liquid-like at first; builds collagen over time | Thicker, provides immediate structure |
| FDA-Approved Areas | Face (off-label for body areas) | Face & Hands (off-label for body contouring) |
| Dilution Variability | Can be diluted for skin tightening & biostimulation | Typically used as a structured filler but can be hyper-diluted for skin improvement |
| Risks & Side Effects | Temporary swelling, bruising, nodule formation (if improperly placed) | Temporary swelling, bruising, potential for nodules if injected superficially |
| Reversibility | ❌ Not reversible | ❌ Not reversible |
Key Differences
- Sculptra is a gradual collagen stimulator that requires multiple sessions but lasts longer.
- Radiesse provides instant volume and also stimulates collagen but doesn’t last as long.
- Radiesse can be used in the hands, while Sculptra is mainly for the face (though both are used off-label for skin tightening when diluted).
- Sculptra is more liquid and works over time, whereas Radiesse is thicker and provides immediate support.